Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infectionOmicron BA.4/BA.5 탈출 중화 면역 BA.1 감염Article Published on 2022-08-102022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, [키워드] absence B.1.1.529 change Decline decrease elicited fold Immunity individuals infected individuals Infection lineages neutralization neutralizing immunity omicron Receptor binding domain SARS-CoV-2 selective South Africa Spike receptor binding domain subsequent Substitution substitutions the strongest vaccinated individual vaccinated individuals vaccination virus Virus neutralization viruses [DOI] 10.1038/s41467-022-32396-9 PMC 바로가기 [Article Type] Article
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proteomics. proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
A Qualitative Comparison of the Abbott SARS-CoV-2 IgG II Quant Assay against Commonly Used Canadian SARS-CoV-2 Enzyme Immunoassays in Blood Donor Retention Specimens, April 2020 to March 20212020년 4월부터 2021년 3월까지 헌혈자 보유 표본에서 일반적으로 사용되는 캐나다 SARS-CoV-2 효소 면역분석에 대한 Abbott SARS-CoV-2 IgG II 정량 분석의 정성적 비교Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval Abbott Abbott SARS-CoV-2 IgG aggregate Analysis analyzed anti-S anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Anti-spike antibody approach assays Blood donors can be used Canada Characteristics characterized Chicago collected detect ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays full-length spike glycoprotein glycoprotein gold gold standard house identify IgG IgG response IgG responses Laboratory methods comparisons nucleocapsid positive provide Qualitative qualitative test RBD Receptor binding Receptor binding domain recognizing reference standard Research retention SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigens SARS-CoV-2 variant scored sensitivity serology Seropositivity specificity specimen spike glycoprotein Spike. standard error the SARS-CoV-2 the strongest threshold viral antigens wild-type [DOI] 10.1128/spectrum.01134-22 PMC 바로가기 [Article Type] Article
IgG Anti-Spike Antibodies and Surrogate Neutralizing Antibody Levels Decline Faster 3 to 10 Months After BNT162b2 Vaccination Than After SARS-CoV-2 Infection in Healthcare WorkersIgG 항스파이크 항체 및 대리 중화 항체 수준은 의료 종사자의 SARS-CoV-2 감염 후보다 BNT162b2 백신 접종 후 3~10개월 더 빠르게 감소합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE-2 anti-S Anti-spike antibody Antibody titers Beta Beta variant binding BNT162b2 Cohort concern COVD-19 COVD-19 serological testing COVID-19 Decline dose expressed faster HCW Health care Health care worker health care workers highest humoral immune response hybrid IgG Immunity Infection Level linear linear relationship Live virus Month natural infection neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron predicted Randomly ranged reduced resulting SARS-CoV-2 SARS-COV-2 infection selected sensitivity serological Serological testing spike surrogate the strongest Type vaccination vaccination. variant VoC wild type worker [DOI] 10.3389/fimmu.2022.909910 PMC 바로가기 [Article Type] Article
Soluble IL-2R Levels at Baseline Predict the Development of Severe Respiratory Failure and Mortality in COVID-19 Patients기준선에서 가용성 IL-2R 수준은 COVID-19 환자에서 심각한 호흡 부전 및 사망의 발병을 예측합니다Article Published on 2022-04-102022-09-11 Journal: Viruses [Category] 바이오마커, [키워드] 95%CI Admission Algorithm Anakinra Biomarker change clinical outcomes coronavirus coronavirus disease Coronavirus disease-19 Corticosteroid Corticosteroids COVID-19 Critical cut-off Delta development died discharge disease severity Endpoint failure Follow-up hazard ratio Immunoglobulin Immunotherapy interquartile range Intravenous immunoglobulin Intubated intubation Laboratory Level Local local treatment marker median age moderate disease Mortality on admission Patient positive predict Predictive Predictive value receptor respiratory Respiratory failure risk Risk factors risk stratification severe disease severe respiratory failure significantly higher soluble interleukin-2 receptor. SRF Stratification the strongest Tocilizumab Treatment were measured [DOI] 10.3390/v14040787 PMC 바로가기 [Article Type] Article
Specialized interferon action in COVID-19코로나19에 특화된 인터페론 작용Article Published on 2022-03-152022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘, 진단, [키워드] Activation Antiviral association C-reactive protein cell types circulating clinical marker clinical markers COVID-19 COVID-19 pathology CyTOF cytokine diagnostic disease severity Effect endothelial damage example Hospitalization hospitalized COVID-19 patients IFN IFN signaling IFNA2 IFNA6 IFNB1 IFNg IFNs Immune cell immune cell types immune cells immune marker Impact Implications interferon interferon. Kynurenine Kynurenine pathway lymphocyte lymphoid marker neutrophil pathology platelet activation poor prognosis Protective proteomics SARS-CoV-2 Seroconversion severe disease Signaling significant decrease subset the strongest therapeutic transcriptional response type I unique [DOI] 10.1073/pnas.2116730119 PMC 바로가기 [Article Type] Article
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severityGPCR 및 RAS 관련 분자를 표적으로 하는 자가항체는 COVID-19 중증도와 연관Article Published on 2022-03-092022-09-11 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] AGTR1 alteration antibody antibody levels association autoantibodies autoantibody characterized Chemokine receptor chemokine receptor CXCR3 Clinical severity component COVID-19 COVID-19 disease COVID-19 disease severity cross-sectional cross-sectional study CXCR3 deregulated disease severity G protein G protein-coupled receptor G protein-coupled receptors healthy control healthy controls human biology identify immune individuals Mild Mild COVID-19 disease moderate Pathogenesis Patient predict Previous studies previous study severe disease severity Systemic autoimmune diseases target targets the disease the strongest with COVID-19 [DOI] 10.1038/s41467-022-28905-5 PMC 바로가기 [Article Type] Article
Neutralizing Antibody Activity Against the B.1.617.2 (delta) Variant Before and After a Third BNT162b2 Vaccine Dose in Hemodialysis Patients혈액 투석 환자에서 세 번째 BNT162b2 백신 접종 전후의 B.1.617.2(델타) 변이체에 대한 중화 항체 활성Article Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] activity addition Against Anti-RBD antibodies Anti-RBD antibody B.1.617.2 BNT162b2 correlation COVID-19 COVID-19 vaccination delta variant demonstrated determined by dialysis Epitopes Hemodialysis high risk Humoral immunity IgG IgG antibodies IgG antibody Immune escape Immunity immunocompromised individuals IQR Live virus median neutralization Neutralizing Neutralizing activity Patient SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes second vaccination seroconversion rate seroconverted Seropositivity severe COVID-19 significantly higher the strongest vaccination vaccine dose variant variants variants of concern variants of concern. was performed [DOI] 10.3389/fimmu.2022.840136 PMC 바로가기 [Article Type] Article
Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents이전 SARS-CoV-2 감염, 연령 및 노쇠는 요양원 거주자의 6개월 백신 유도 항스파이크 항체 역가와 관련이 있습니다Article Published on 2022-03-012022-09-11 Journal: Journal of the American Medical Directors Associat [Category] MERS, SARS, 진단, 치료법, [키워드] 95% confidence interval ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age All participant All participants analyzed angiotensin Angiotensin-converting enzyme Anti-spike anti-spike antibody antibody Antibody Response Antibody titer Antibody titers BNT162b2 Clinical outcome clinical outcomes cohort study Comorbidity Comprehensive coronavirus correlated COVID-19 demonstrated determinant determinants Evidence evidence of examined female frailty home in vitro independent of Infection log-transformed Long-term care longitudinal longitudinal cohort study make up Messenger RNA morbidity morbidity and mortality naïve Neutralization assay neutralization capacity nucleocapsid Nursing nursing home nursing homes Older participant post vaccination RBD receptor Receptor binding domain resident respiratory risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2.0 Serum Neutralization setting severe acute respiratory syndrome Coronavirus significantly significantly lower the strongest timepoints titer vaccination Vaccine vaccine. vulnerable population was performed [DOI] 10.1016/j.jamda.2021.12.001 PMC 바로가기 [Article Type] Article